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KMID : 0377619960610080631
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Korean Jungang Medical Journal
1996 Volume.61 No. 8 p.631 ~ p.640
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Effects of Vitamin E Administration on the Resistance of Mice to Infection with Cryptococcus neoformans or Candida albicans
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Abstract
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The previous studies found that vitamin E(VE) administration increases the humoral and cellular immune response in mice. The present study was undertaken to investigate to know the effects of VE administration on the resistance of mice to two commensal yeasts, Cryptococcus neoformans and Candida albicans which cause opportunistic infections in immunocompromised or severeiy debilitated hosts. Mice were daily treated with intramuscular injection of 300 mg/mouse of VE on 10 consecetive days before intravenous inoculation of 5 X 105 CFU of C. neoformans or C albicans. The colony forming units(CFU) of C neoformans in the lungs, brains, livers, spleens and kidneys of VE-treated and control mice were enumerated 9 days after the infection. VE administration significantly reduced the number of C. neoformans recovered from the above organs examined. Furtheremore, VE adnninistration enhanced survival of mice that had been experimentally infected with C. neoformans compared with control mice. VE administration also reduced the numbers of C. albicans recovered from kidneys of experimentally infected mice. The effects of VE administration on delayed-type hypersensitivity reaction to cryptococcal culture filtrate(CneF) antigen was also assessed and it was found that VE administration enhanced the delayed-type hypersensitivity reaction to CneF. Taken together, the present data strongly suggested that VE administration may increase the resistance to infections with C. neoformans or C. albicans.
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KEYWORD
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